88 Food Antigen IgG with C3d/C3b - Serum

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Turnaround Time: 10-15 days
Test Type: Kit Based - Serum
Stability Time:

1 week at 4 degrees Celsius (refrigerate).  These stabilities offer you the ability to draw on a Friday, and ship the samples on Monday.  We ask that they are received by the laboratory within 6 days of collection.  Do NOT freeze samples. 


Various Antibodies and Their Meaning
IgG (immunoglobulin G, total) are antibodies that provide long-term resistance to infections and have a much longer half-life than an IgE allergy. This food sensitivity can be more subtle, and many people live with it for years, if not their entire lives. Sensitivity symptoms range from fatigue, headache/nausea, seizures, hyperactivity, bloating, mood changes, or dark circles under the eyes. IgG symptoms typically occur within 3-72 hours after the offending food was ingested and they will create ongoing inflammation that can make most conditions worse. Because they can present at such varied times, it is hard to isolate from a diet history alone, and testing becomes particularly useful.

The degree and severity of symptoms vary greatly from person to person because of genetic makeup. The complete elimination of IgG positive foods may bring about important improvements in symptoms of irritable bowel syndrome, autism, ADHD, cystic fibrosis, rheumatoid arthritis, and epilepsy, as demonstrated in numerous clinical studies. It is important to get tested for food sensitivities to know what foods work for the patient’s body and what foods don’t. If you are only looking at allergies, or IgE, then you would miss the IgG mediated symptoms, creating an incomplete patient picture.
C3 (complement component 3) is a protein of the innate immune system that is activated by microorganisms in the absence of an antibody. When C3d is activated in response to an antigen, the C3 portion attaches to the antigen. This activation, even though it is independent, will amplify the reaction that occurs with total IgG greatly increasing inflammation and symptoms of sensitivity. This same reaction that was designed to amplify inflammation to microorganisms, can be triggered in response to foods. If complement is present, it will amplify an IgG reaction as much as 1000 to 10,000-fold. Therefore, tests that only measure IgG may miss the reactions to foods that are most clinically relevant. C3 will be cleaved into multiple C3 breakdown products, and all of these play a role in increasing inflammatory response to foods.

Collection Details:

Patient Preparation:

Click here for collection instructions

Collection Instructions:

Your kit should contain:

  • 1 cold pack
  • 1 requisition form
  • 1 biohazard bag with gauze pad
  • 1 silver insulated envelope
  • 1 prepaid shipping label
  • 1 lab shipping pack (UPS)
  • 3 SST Tubes
  • 1 transfer pipette
  • 1 White top 10mL transport tube


Collection instructions:


  1. Place a cold pack in freezer for at least 4 hours minimum before shipping.
  2. Collect the blood in the three (3) SST tubes provided.
  3. Allow the blood to sit for 30 minutes.
  4. Centrifuge the blood for 15 minutes.
  5. Transfer the serum from the SST tubes to the White top 10 mL transfer tube.
  6. Using the permanent market, write the patient’s first and last name, date of birth, and date of collection on each sample tube.
  7. Store the sample in a 2-8 degree Celsius refrigerator until ready to ship.  Do not freeze.  Frozen samples will not be processed.


Shipping Instructions

  1. Make sure the specimen tubes are properly labeled. 
  2. Place the tube(s) inside of the biohazard bag and seal the bag.  Do not remove the gauze pad.
  3. Complete the Test Requisition Form, fold and place the form within the outer pocket of the biohazard bag.
  4. Place the biohazard bag into the silver insulated envelope.
  5. Place the frozen cold pack inside the silver insulated enveloped.
  6. Seal the envelope and place it inside the kit box. 
  7. Place the kit of box inside the lab mailing pack.
  8. Attach the prepaid shipping label.