Actin (Smooth Muscle) Antibody (ASMA)

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Turnaround Time: 1-3 days
CPT Code:


Test Type: 1mL Serum
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

• Negative: 0−19

• Weak positive: 20−30

• Moderate to strong positive: >30


Detection of antibodies aids in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC).

Antiactin antibodies have been reported at low levels in 3% to 18% of sera from the general healthy population. The presence of immune complexes in the patient's sample may produce false positives in this assay. Not all smooth muscle positive samples will have actin antibodies. Additional Information

Actin antibodies are found in 52% to 85% of patients with autoimmune hepatitis or chronic active hepatitis and in 22% of patients with primary biliary cirrhosis.

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Room Temperature.