Alpha-2-Macroglobulin, Quantitative

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Turnaround Time: 1 - 3 days
CPT Code:


Test Type: Serum, 1mL
Stability Time:



Room temperature

3 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

110-276 mg/dL


α2-macroglobulin assay is of major significance in the differential diagnosis of nephrotic syndrome, where an elevated α2-macroglobulin:albumin ratio is indicative of postrenal hematuria. In patients with liver cirrhosis and diabetes, the level of α2-macroglobulin is found to be elevated.

In hyperfibrinolytic states, after major surgery, in septicemia and severe hepatic insufficiency, the measured levels of α2-macroglobulin are often low. Patients with acute pancreatitis exhibit low serum concentrations that correlate with the severity of the disease.

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Separate serum from cells within 30 to 60 minutes after collection. Transfer specimen to a plastic transport tube.

Maintain specimen at room temperature.