Anti-RNA Polymerase III (RDL)

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Turnaround Time: 14-21 days
CPT Code:


Test Type: 1 mL Serum
Stability Time:

7 days Room Temperature

Reference Range:

Reference Interval

• Negative: <20 Units

• Weak Positive: 20–39 Units

• Moderate Positive: 40–80 Units

• Strong Positive: >80 Units



Use: The detection of anti-RNAP III antibodies is useful in the diagnosis of SSc and for the identification of patients at risk for developing progressive skin thickening and renal crisis. The prevalence of IgG RNAP III antibodies is from 3 - 58% in SSc patients.


Methodology: Enzyme immunoassay (EIA)



Collection Details:

Collection Instructions:

Specimen: Serum

Volume: 1 mL

Minimum Volume: 0.3 mL (Note: This volume does not allow for repeat testing.)

Container: Red-top tube or gel-barrier tube

Collection: Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions: Refrigerate or freeze.