Antichromatin Antibodies

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Turnaround Time: 1 - 3 days
CPT Code:


Test Type: 1 mL Serum, 1mL
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3


Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE). Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.

Burlingame RW, Cervera R. Anti-chromatin (anti-nucleosome) autoantibodies. Autoimmun Rev. 2002 Dec; 1(6):321-328. PubMed 12848987

Sherer Y, Gorstein A, Fritzler MJ, Schoenfeld Y. Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients. Semin Arthritis Rheum. 2004 Oct; 34(2):507-537. PubMed 15505768

Simón JA, Cabiedes J, Ortiz E, Alcocer-Varela J, Sánchez-Guerrero J. Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker. Rheumatology (Oxford). 2004 Feb; 43(2):220-224. PubMed 13130152

Stinton LM, Barr SG, Tibbles LA, et al. Autoantibodies in lupus nephritis patients requiring renal transplantation. Lupus. 2007; 16(6):394-400. PubMed 17664229

Villata D, Tozzoli R. Anti-chromatin (nucleosome) autoantibodies. In: Gershwin ME, Meroni P-L, Schoenfeld Y, eds. Autoantibodies. 2nd ed. Amsterdam, The Netherlands: Elsevier, BV; 2007:141-149.

Collection Details:

Collection Instructions:

Gel-barrier tube or red-top tube.

If tube other than gel-barrier tube is used, transfer the separated serum to a plastic transport tube.

Room temperature.