Antidiuretic Hormone (ADH), Plasma

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Category:

Turnaround Time: 6 - 12 days
CPT Code:

84588

Test Type: 2 mL Plasma, frozen

Overview:

Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndrome of ectopic ADH production.

Results of this test are labeled for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established by the manufacturer. The result should not be used for treatment or for diagnostic purposes without confirmation of the diagnosis by another medically established diagnostic product or procedure. The performance characteristics were determined by LabCorp.

ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.

Cowley AW Jr, Cushman WC, Quillen EW Jr, Skelton MM, Langford HG. Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake. Hypertension. 1981 May-Jun; 3(3 Pt 2):I93-100. PubMed 7262983

Malvin RL. Possible role of the renin-angiotensin system in the regulation of antidiuretic hormone secretion. Fed Proc. 1971 Jul-Aug; 30(4):1383-1386. PubMed 4326738

Pullan PT, Clappison BH, Johnston CI. Plasma vasopressin and human neurophysins in physiological and pathological states associated with changes in vasopressin secretion. J Clin Endocrinol Metab. 1979 Oct; 49(4):580-587. PubMed 479348

Rascher W, Rauh W, Brandeis WE, Huber KH, Schärer K. Determinants of plasma arginine-vasopressin in children.Acta Paediatr Scand. 1986 Jan; 75(1):111-117. PubMed 3953266

Collection Details:

Patient Preparation:

No isotopes administered within 24 hours prior to venipuncture.

Collection Instructions:

Lavender-top (EDTA) tube.

Centrifuge in a refrigerated centrifuge, separate plasma, and freeze immediately. Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Freeze.