Antidiuretic Hormone (ADH) Profile

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Turnaround Time: 7 - 10 days
Test Type: 1 mL serum, refrigerated and 2 mL plasma, frozen
Reference Range:

• ADH: 0.0−4.7 pg/mL

• Osmolality:

− Neonates: May be as low as 266 mOsmol/kg

− 0 to 60 years: 275−295 mOsmol/kg

− >60 years: 280−301 mOsmol/kg


ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.

Cowley AW Jr, Cushman WC, Quillen EW Jr, et al. Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake. Hypertension. 1981; 3(3 Pt 2):I93-100. PubMed 7262983

Malvin RL. Possible role of the renin-angiotensin system in the regulation of antidiuretic hormone secretion. Fed Proc. 1971; 30(4):1383-1386. PubMed 4326738

Pullan PT, Clappison BH, Johnston CI. Plasma vasopressin and human neurophysins and physiological and pathological states associated with changes in vasopressin secretion. J Clin Endocrinol Metab. 1979; 49(4):580-587. PubMed 479348

Collection Details:

Patient Preparation:

No isotopes administered 24 hours prior to venipuncture.

Collection Instructions:

Gel-barrier tube and lavender-top (EDTA) tube.

Draw serum and plasma samples and separate from cells using a refrigerated centrifuge. Transfer separated samples into clearly labeled “plasma” and “serum” plastic transport tubes. Freeze plasma immediately and refrigerate serum. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Freeze plasma immediately. Refrigerate serum.