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Register NowAntinuclear Antibodies (ANA) Profile, 09-biomarkers, by Multiplex Immunoassay
Create a Free Account to View PricesTurnaround Time: 1 - 3 days
CPT Code:
86225, 86235(8)
Test Type: 1 mL Serum
Stability Time:
|
Temperature |
Period |
|---|---|
|
Room temperature |
14 days |
|
Refrigerated |
14 days |
|
Frozen |
14 days |
|
Freeze/thaw cycles |
Stable x3 |
Reference Range:
Anti-DNA (DS) Ab Qn IU/mL 0 - 9
Negative <5
Equivocal 5 - 9
Positive >9
RNP Antibodies AI 0.0 - 0.9
Smith Antibodies AI 0.0 - 0.9
Antiscleroderma-70 Antibodies AI 0.0 - 0.9
Sjogren's Anti-SS-A AI 0.0 - 0.9
Sjogren's Anti-SS-B AI 0.0 - 0.9
Antichromatin Antibodies AI 0.0 - 0.9
Anti-Jo-1 AI 0.0 - 0.9
Anti-Centromere B Antibodies AI 0.0 - 0.9
Autoantibody Disease Association
------------------------------------------------------------
Condition Frequency
--------------------- ------------------------ ---------
Antinuclear Antibody, SLE, mixed connective
Direct (ANA-D) tissue diseases
--------------------- ------------------------ ---------
dsDNA SLE 40 - 60%
--------------------- ------------------------ ---------
Chromatin Drug induced SLE 90%
SLE 48 - 97%
--------------------- ------------------------ ---------
SSA (Ro) SLE 25 - 35%
Sjogren's Syndrome 40 - 70%
Neonatal Lupus 100%
--------------------- ------------------------ ---------
SSB (La) SLE 10%
Sjogren's Syndrome 30%
--------------------- ----------------------- ---------
Sm (anti-Smith) SLE 15 - 30%
--------------------- ----------------------- ---------
RNP Mixed Connective Tissue
Disease 95%
(U1 nRNP, SLE 30 - 50%
anti-ribonucleoprotein) Polymyositis and/or
Dermatomyositis 20%
--------------------- ------------------------ ---------
Scl-70 (antiDNA Scleroderma (diffuse) 20 - 35%
topoisomerase) Crest 13%
------------------- -- ------------------------ ---------
Jo-1 Polymyositis and/or
Dermatomyositis 20 - 40%
--------------------- ------------------------ ---------
Centromere B Scleroderma - Crest
variant 80%
Overview:
Detect antibodies associated with SLE and mixed connective tissue disease. Anti-Sm is highly specific for SLE. Anti-RNP is found with a variety of rheumatoid diseases. RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1 are extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells.
Collection Details:
Collection Instructions:
This test is intended to be used as a follow-up to Antinuclear Antibodies (ANA) Direct [164855].
Red-top tube or gel-barrier tube.
Room temperature.