Antiphosphatidylserine, IgA, IgG, IgM

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Turnaround Time: 2 - 4 days
CPT Code:


Test Type: 1 mL Serum


An adjunct to β2-glycoprotein and anticardiolipins in diagnosing aPS (antiphospholipid syndrome) for assessing thrombotic risk and other obstetric complications such as miscarriage or fetal growth restrictionAntiphospholipid antibodies are a heterogeneous group of immunoglobulins that bind to several anionic phospholipids, including cardiolipin and phosphatidylserine. High serum levels of antiphospholipid antibodies are frequently detected in patients with autoimmune (ie, SLE) and nonautoimmune diseases, as well as in apparently healthy individuals. These antibodies have been associated with an increased risk for recurrent arterial and venous thrombotic events, thrombocytopenia, and fetal loss. These manifestations are the main features of the antiphospholipid syndrome. Antiphospholipid antibodies are detected either by ELISAs using cardiolipin or other negatively-charged phospholipids as the antigen (anticardiolipin antibodies) or coagulation assays (lupus anticoagulants). Unlike cardiolipin, phosphatidylserine is a more physiologically relevant phospholipid due to its presence in cell membranes of endothelial cells and platelets and its role in the coagulation cascade. The detection of antiphosphatidylserine (aPS) antibodies by ELISA has been recommended for the serological diagnosis of antiphospholipid syndrome. Patients with positive reactions to both cardiolipin and phosphatidylserine are more likely to have clinical complications than those positive for only one. Higher prevalence and mean serum levels of antiphosphatidylserine antibodies have been reported in autoimmune patients. In addition, antiphosphatidylserine antibodies in SLE patients correlated with clinical manifestations of antiphospholipid syndrome and their pathogenic role has been demonstrated in a murine model.

Barna LK, Triplett DA, Foster WM, et al. A study of relationships among antiphosphatidylserine and anticardiolipin antibodies, the lupus anticoagulant and clinical implications. Lupus. 1994; 3:357.

Corgenix Inc. The significance of IgA antiphosphatidylserine (aPS) antibodies. The Reader. 2000; 10(2). Antiphosphatidylserine Semiquantitative Test Kits [package insert ]. Keedy KJ, Buckner TR, Taylor DO, et al. Antiphospholipid syndrome: Detection and clinical significance of antiphosphatidylserine antibodies by ELISA. 49th Annual AACC Clinical Laboratory Meeting, July 22nd-24th, 1997.

Keedy KJ, Santos M, Lopez L. Antiphosphatidylserine antibodies require beta 2-glycoprotein 1 as cofactor in ELISA. Lupus. 1994: 3:327.

Keedy KJ, Santos M, Lopez L. Prevalence and clinical significance of antiphosphatidylserine antibodies. Arthritis Rheum. 1994; 37:S392.

Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006 Feb; 4(2):295-306. PubMed 16420554

Yodfat O, Blank M, Krause I, Schoenfeld Y. The pathogenic role of antiphosphatidylserine antibodies: Active immunization with the antibodies leads to the induction of antiphospholipid syndrome. Clin Immunol Immunopathol. 1996 Jan; 78(1):14-20. PubMed 8599879

Zuazu-Jausoro I, Oliver A, Monserrat I, et al. Importance of antiphosphatidylserine antibodies in patients with lupus anticoagulant. Analysis of 30 cases. Med Clin (Barc). 1990 Jul 7; 95(6):210-213. PubMed 2123507

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Separate serum from cells by centrifugation after clot formation.