Turnaround Time: 1 - 2 days
CPT Code:


Test Type: 2 mL Serum (preferred) or plasma
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:


Apolipoprotein B (mg/dL)


Borderline High


Very High


90 – 99

100 – 130



ASCVD Risk Category

Therapeutic Target APO B (mg/dL)

Very High Risk

<80 (if extreme risk <70)

High Risk


Moderate Risk



LDL and its major protein, apolipoprotein B, play an essential role in lipid transport and metabolism. Apo B may regulate cholesterol synthesis through its interaction with specific cell membrane receptors and by inhibition of HMG Co A reductase. This enzyme has been identified as the rate controlling enzyme in cholesterol biosynthesis. Apo B may be important in the genesis of atherosclerosis and its quantitation useful in the evaluation of patients at risk for or having coronary atherosclerosis (CAD). High levels indicate increased risk for CAD.

Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May; 58(5):854-868. PubMed 22371482

Contois JH, McConnell JP, Sethi AA, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009 Mar;55(3):407-419. PubMed 19168552

Jacobson TA, Ito MK, Maki KC, et al. National lipid association recommendations for patient-centered management of dyslipidemia: part 1–full report. J Clin Lipidol. 2015 Mar-Apr;9(2):129-169. PubMed 25911072

Collection Details:

Patient Preparation:

Patient must be fasting 12 to 14 hours.

Collection Instructions:

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube

Separate serum or plasma from cells. Transfer specimen to a plastic transport tube.

Maintain specimen at room temperature.