Cancer Antigen (CA) 27.29

Overview:

Manage patients with metastatic carcinoma of the breast

For the quantitative determination of CA 27.29 antigen in serum of patients previously treated for stage II or stage III breast cancer. Serial testing for CA 27.29 antigen in patients who are clinically free of disease should be used in conjunction with other clinical methods for the early detection of recurrence. CA 27.29 is a highly polymorphic glycoprotein belonging to the mucin family and is the product of the muc-1 gene. It is most useful using serial measurements to monitor both the course of disease and response to therapy because the direct correlation of changing levels of CA 27.29 with clinical status. In patients with known metastases, a reduction in levels of this marker indicates a good response to treatment while increasing levels indicate resistance to therapy and progressive disease and justify further clinical evaluation and regular monitoring. It has also recently been shown that an elevation of CA 27.29 levels above the upper limit of normal in patients with no clinical evidence of disease is an early indicator of recurrence. An elevated serum CA 27.29 level in patients in remission of stage II or III breast cancer provided a positive predictive value of 83.3% for recurrent disease, with an average lead time of 5.3 months before recurrence was clinically established.

Abbate I, Correale M, Musci MD, et al. Monoclonal antibody B27.29 against mucinous breast cancer associated antigen CA 27.29 in breast cancer. Br Cancer Res and Treatment. 1991; 19(2):123.

Chan DW, Beveridge RA, Muss H, et al. Use of Truquant BR radioimmunoassay for early detection of breast cancer recurrence in patients with stage II and stage III disease. J Clin Oncol. 1997 Jun; 15(6):2322-1318. PubMed 9196146

Hayes DF, Zurawski VR Jr, Kufe DW. Comparison of circulating CA 15-3 and carcinoembryonic antigen levels in patients with breast cancer. J Clin Oncol. 1986 Oct; 4(10):1542-1550. PubMed 2428949

Linsley PS, Brown JP, Magnani JL, Horn D. Monoclonal antibodies reactive with mucin glycoprotein found in sera from breast cancer patients. Cancer Res. 1988 Apr 15; 48(8):2138-2148. PubMed 2450646

Reddish MA, Helbrecht N, Almeida A, Madiyalakan R. Epitope mapping of Mab B27.29 within the peptide core of the malignant breast cancer associated mucin antigen coded for by the human MUC 1 gene. J Tumor Marker Oncol. 1992 Jan 1; 7(1):19-27.1:31 PM 5/24/2021