Catecholamines, Fractionated, Urinary Free and Vanillylmandelic Acid (VMA), 24-Hour Urine

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Turnaround Time: 6 - 9 days
CPT Code:

82384, 84585

Test Type: 60 mL aliquot Urine (24-hour)


Collection is of greatest value for evaluation of hypertension if performed during a hypertensive episode. Test is used to evaluate hypertension, especially if paroxysmal and to evaluate orthostatic hypertension. Test is also useful in the diagnosis of pheochromocytoma and in the diagnosis and follow-up of neuroblastoma and ganglioneuroblastoma, retinoblastomas, carcinoid tumors, carotid body tumors, and stress. Preoperative evaluation of neoplasia of childhood, especially when the tumor is in or about the adrenals. Evaluate multiple endocrine adenomatosis. Evaluate patient with medullary carcinoma of thyroid (for coexistent pheochromocytoma).

Collection Details:

Patient Preparation:

See Catecholamines, Fractionated, Urinary Free, 24-Hour [004176] and Vanillylmandelic Acid (VMA), 24-Hour Urine [004143]. See the Interfering Substances Appendix.

Collection Instructions:

Include 24-hour total urine volume on the test request form and the date and time collection started and finished. Note: If original container is received with pH >3, but <5, adjust pH to <3 with 6N HCl.

Plastic urine container with 30 mL 6N HCl. Caution: Strong acid. LabCorp item number for this container is N° 21584.

Preservative must be added to the container prior to the start of collection. Collect 24-hour urine. Mix well. Send 60 mL aliquot. Record total 24-hour urine volume on test request form. Final pH must be <5. Note: Do not use boric acid or acetic acid as a preservative.