Cold Agglutinin Titer, Quantitative

Detection of the presence of cold agglutinins in patients with suspected cold agglutinin disease.

False-negative results may occur if the sample is refrigerated prior to the separation of the serum from the red blood cells. This test is not a direct measure of the clinical significance of the cold agglutinin and must be used in conjunction with the patient’s clinical presentation and other laboratory values. Normal individuals may have low levels of cold agglutinins that have no clinical significance.

Fung MK, Grossman JB, Hillyer CD, Westoff CM, eds. AABB Technical Manual. 18th ed. Bethesda, Md: American Association of Blood Banks;2014.

Petz LD, Garratty G. Immune Hemolytic Anemias. 2nd ed. New York: Churchill Livingstone/Elsevier Science;2004.