Dehydroepiandrosterone (DHEA), LC/MS-MS

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Category:

Turnaround Time: 4 - 6 days
CPT Code:

82626

Test Type: 1 mL Serum
Stability Time:

Temperature

Period

Room temperature

6 hours

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3
Reference Range:

See table.1,2

 

Age (y)

Range (ng/dL)

0 to 5

0−67

6 to 7

0−110

8 to 10

0−185

11 to 12

0−201

13 to 14

0−318

15 to 16

39−481

17 to 19

40−491

>19

31−701

Overview:

Evaluate adrenal carcinomas that frequently secrete large amounts of DHEA

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Dehydroepiandrosterone (DHEA) is a steroid that is produced by both the adrenal cortex and the testis.3 The levels of this steroid increase before the onset of puberty (adrenarche) and decrease significantly with age.4 DHEA and DHEA-S are the major precursors of 17-ketosteroids.

1. Ducharme JR, Forest MG, De Peretti E, et al. Plasma adrenal and gonadal sex steroids in human pubertal development. J Clin Endocrinol Metab. 1976; 42(3):468-476. PubMed 130382

2. Tietz NW, ed. Clinical Guide to Laboratory Tests. 3rd ed. Philadelphia, Pa: WB Saunders Co;1995:195-196.

3. de Peretti E, Forest M. Unconjugated dehydroepiandrosterone plasma levels in normal subjects from birth to adolescence in humans: The use of a sensitive radioimmunoassay. J Clin Endocrinol Metab. 1976; 43(5):982-991. PubMed 186482

4. Carlstrom K, Brady S, Lunell NO, et al. Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: Differences related to age and sex. Maturitas. 1988; 10(4):297-306. PubMed 2976116

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Sample must be refrigerated due to limited stability at room terperature. Freeze if unable to maintain refrigerated.