DHEA Sulfate (DHEA-S) (1134)

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CPT Code:


Test Type: Serum 1.0 mL Kit Based
Stability Time:


Refrigerated: 14 days


DHEA-S is an androgenic steroid secreted by the adrenal cortex and is the major androgen precursor in females.


Immunoassay-Competitive principle


  • Elevated DHEA-S values aid in the diagnosis of hirsutism and virilism
  • Elevated DHEA-S levels may be useful for the diagnosis of:1-4
    • All forms of excess androgen
    • Hyperprolactinemia
    • Polycystic ovarian syndrome
    • Exclusion of an androgen producing tumor of the adrenal cortex
    • Genetic enzyme defects of the adrenal cortex (adrenogenital syndrome)
    • Hyperplasia of the adrenal cortex as well as androgen producing tumors
  • High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.


  1. Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in men with androgen deficiency syndromes: Endocrine Society clinical practice guidelines. J Clin Endorcinol Metab. 2010;95(6):2536-2559.
  2. Santen RJ, Allred DC, Ardoin SP, et al. Postmenopausal hormone therapy: an Endocrine Society scientific statement. J Clin Endocrinol Metab. 2010;95(7 Suppl 1):s1-s66.
  3. Kopper NW, Gudeman J, Thompson DJ. Transdermal hormone therapy in postmenopausal women: a review of the metabolic eff ects and drug delivery technologies. Drug Des Devel Ther. 2008;2:193-202.
  4. Goodman N, Cobin RH. Reproductive disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:190-228.

Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST / Tiger Top)


Transport Temperature

Refrigerated (ship on frozen cold packs)


Refrigerated: 14 days