Diabetes Comorbidity Assessment (023400)

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Category:

Turnaround Time: Within 1 day
CPT Code:

80061, 82565, 82570, 82043

Test Type: 3 mL serum or plasma and 10 mL urine
Stability Time:

Temperature

Period

Room temperature

3 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x2
Reference Range:

LDL cholesterol cannot be calculated if triglyceride is >400 mg/dL.

Overview:

This test is intended to help inform the clinician about the presence of hyperlipidemia as an index to cardiovascular disease and to identify patients with chronic kidney disease.

LDL cholesterol cannot be calculated if triglyceride is >400 mg/dL.

The relationship between diabetes, cardiovascular disease, and chronic kidney disease is widely recognized. Among individuals with type 2 diabetes, cardiovascular disease is the leading cause of morbidity and mortality. Chronic kidney disease occurs in 20% to 40% of patients with diabetes and may be present at the time of diagnosis.

While not considered to be a clinical entity itself, individuals with prediabetes are at increased risk for diabetes and cardiovascular disease. Additionally, observational evidence has linked prediabetes with early nephropathy, chronic kidney disease, small fiber neuropathy, diabetic retinopathy, and increased risk of macrovascular disease.

American Diabetes Association. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2018.Diabetes Care. 2018 Jan; 41(Suppl 1):S86-S104. PubMed 29222380

Eckel RH, Kahn R, Robertson RM, Rizza RA. Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association. Circulation. 2006 Jun 27;113(25):2943-2946. PubMed 16801475

Executive Summary of The Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. JAMA. 2001 May 16;285(19):2486-2497. PubMed 11368702

Lamarche B, Tchernof A, Moorjani S, et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study. Circulation. 1997 Jan 7;95(1):69-75. PubMed 8994419

Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. Non-HDL cholesterol, apolipoproteins A-1 and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005 Jul 20;294(3):326-333. PubMed 16030277

Collection Details:

Patient Preparation:

Patient should be on a stable diet, ideally for two to three weeks prior to collection of blood, and should fast for 12 to 14 hours before collection of the specimen.

Collection Instructions:

State patient's age and sex on the request form.

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube and plastic urine container.

Separate serum or plasma from cells within 45 minutes of collection. Lipid panels are best avoided for up to three months following acute myocardial infarction, although cholesterol can be measured in the first 24 hours.

Collect random urine without preservatives. pH must be 4 to 8.

Maintain specimens at room temperature.