Overview:

Use: 
FIB-4 index is reported to be a simple, accurate, non-invasive, and readily available laboratory test index that can help in evaluation of patients with HCV and Non-Alcoholic Fatty Liver Disease (NAFLD) for the presence of liver fibrosis indication for liver biopsy, and other liver-related complications. It was also reported to be concordant with FibroSure test results.

Limitations

Clumping may cause false low count. Platelet satellitism around neutrophils will cause a pseudothrombocytopenia. RBC or WBC fragments including fragmented fragile leukemic cells and neutrophil pseudoplatelets may cause falsely elevated counts.

Methodology:

AST and ALT: Kinetic

Platelet Count: Automated cell counter

 

Collection Details:

Collection Instructions:

Specimen Requirements


Specimen

Serum (preferred) or plasma and whole blood


Volume

1 mL (serum or plasma); fill tube to capacity (whole blood)


Minimum Volume

0.5 mL (serum or plasma); 0.5 mL (whole blood)


Container

Gel-barrier tube or red-top tube or green-top (heparin) tube or lavender-top (EDTA) tube (plasma), and a separate lavender-top (EDTA) tube (whole blood)

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