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Use:
FIB-4 index is reported to be a simple, accurate, non-invasive, and readily available laboratory test index that can help in evaluation of patients with HCV and Non-Alcoholic Fatty Liver Disease (NAFLD) for the presence of liver fibrosis indication for liver biopsy, and other liver-related complications. It was also reported to be concordant with FibroSure test results.
Limitations
Clumping may cause false low count. Platelet satellitism around neutrophils will cause a pseudothrombocytopenia. RBC or WBC fragments including fragmented fragile leukemic cells and neutrophil pseudoplatelets may cause falsely elevated counts.
Methodology:
AST and ALT: Kinetic
Platelet Count: Automated cell counter
Collection Details:
Collection Instructions:
Specimen Requirements
Specimen
Serum (preferred) or plasma and whole blood
Volume
1 mL (serum or plasma); fill tube to capacity (whole blood)
Minimum Volume
0.5 mL (serum or plasma); 0.5 mL (whole blood)
Container
Gel-barrier tube or red-top tube or green-top (heparin) tube or lavender-top (EDTA) tube (plasma), and a separate lavender-top (EDTA) tube (whole blood)
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