GI Pathogen Profile, multiplex PCR

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Turnaround Time: 1 day
CPT Code:
  • 87507
Test Type: Kit-Based, Stool
Reference Range:


0-199 years Negative


The GI Pathogen Profile, uses multiplex PCR system, tests for 14 Viruses, parasites, and bacteria, and offers new opportunities for the rapid, accurate diagnosis and prompt treatment of diarrheal illnesses which can improve patient outcomes and clinical success.

While bacteria and parasites are the primary cause of food & water-borne diarrheal illness (48 million infections/year), the vast majority of acute diarrheal illness is caused not by bacteria or parasites, but by viral infections. In fact, Norovirus is the primary gastrointestinal infection occurring in the United States. Even though testing for pathogenic bacteria and parasite is commonly available, there has been limited availability of viral testing until recently.

Acute gastroenteritis may contribute to patient morbidity and even mortality, if the illness progresses to severe dehydration. Also, the identification of reportable diseases is imperative to prevent large outbreaks, especially for highly contagious or food-borne illnesses, and many gastrointestinal illnesses have very similar clinical presentations.

If your patient has diarrheal illness, you need accurate results quickly. Most GI Pathogen Profile results can be provided within one business day of sample receipt with 99.9% overall negative predictive value. As a result, you can begin targeted treatment immediately, for greater therapeutic efficacy and reduced risk of complications & side effects associated with incorrect treatment or unwarranted antimicrobial administration.

Rapid diagnosis allows for better treatment decisions, as antimicrobial agents have no effect on viral illness, and the indiscriminate use of antibiotics may increase bacterial resistance. Certain pathogenic bacterial and parasitic infections may require antimicrobial treatment, while other infections warrant rehydration and supportive therapies. Knowing the difference allows the treating physician to practice good antimicrobial stewardship.

Use the GI Pathogen Profile as a stand-alone test, or as a complement to our Comprehensive Stool Analysis, to test for the presence of viral infections or to differentiate between possible diarrheagenic strains of E. coli.


Performing Lab: DDINT

Collection Details:

Patient Preparation:

Specimen Requirements
5-8 mL stool (Fill to Line)

Collection Container/Tube
Stool collection container

Transport Container/Tube
Yellow-capped vial (C&S Media), Alternative: Any Carey Blair media tube

Minimum Specimen Volume
2 mL stool (Half full)

Rejection Criteria
Media is expired No media Frozen Stool is in Formalin or Total-Fix

Stability Information
Room temperature: 4 days
Refrigerated: 4 days
Frozen: Unacceptable
37°C/99°F: Not Determined

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