GM1 IgM Autoantibodies

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Category:

Turnaround Time: 5-7 days
CPT Code:

83520

Test Type: Serum, frozen, 0.3 mL
Reference Range:

0 - 30%

 

Overview:

Use: The BUHLMANN™ Anti-GM1 IgM ELISA is intended for the qualitative determination of human IgM autoantibodies directed against monosialotetrahexosylganglioside (GM1) in human serum.1

Limitations: Anti-GM1 IgM seropositivity is supportive but not sufficient to confirm the diagnosis of MMN and the diagnosis of cannot be excluded by seronegativity for Anti-GM1.2-4 Anti-GM1 may also be found in patients with Guillain-Barr syndrome,5-6 acute motor axonal neuropathy, and chronic inflammatory demyelinating polyneuropathy as well as in normal individuals but these are mainly IgG type antibodies.2,7-8 This test, by itself, is not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology: Enzyme-Linked Immunoassay (ELISA) for antibodies to the ganglioside GM11

Collection Details:

Patient Preparation:

Lipemic samples can be avoided by having the patient fast for 12 hours prior to collection.

Collection Instructions:

specimen: Serum, frozen

Volume: 0.3 mL

Minimum Volume: 0.1 mL (Note: This volume does not allow for repeat testing.)

Container: Gel-barrier tube or red-top tube

Collection: Separate serum from cells. Transfer the serum into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen at ≤ -20°C until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.