Single Lab Test

Haptoglobin Genotype Test (887)

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Categories
Performing Lab
:
Boston Heart Diagnostics
Turnaround Time
CPT Code
81479
Test Type

Whole Blood Kit Based

Overview

This test identifies individuals with diabetes or advanced kidney disease who may benefit from vitamin E supplementation. Those individuals with the haptoglobin 2/2 variant are at risk for accelerated oxidative damage due to delayed clearance of haptoglobin-hemoglobin complexes. Vitamin E supplementation (400 IU daily) in those individuals has been demonstrated to reduce the risk of CVD events and CVD death.

  • No increased CVD risk other than from risk associated with underlying conditions
  • Genotype 1/1
  • Genotype 1/2
  • 3-Fold increased CVD risk in patients with diabetes or kidney disease1
  • Genotype 2/2

References:

  1. Cahill LE, Levy AP, Chiuve SE, et al. Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin. J Am Coll Cardiol 2013; 61:728–37.

Methodology - Real-time polymerase chain reaction (PCR)

Collection Details

Patient Preparation:

Collection Instructions:

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