Haptoglobin Genotype Test (887) (Add-on)

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CPT Code:


Test Type: Whole Blood Kit Based
Stability Time:


Refrigerated: 14 days

Reference Range:


  • Genotype 1/1
  • Genotype 1/2

Increased risk

  • Genotype 2/2


This test identifies individuals with diabetes or advanced kidney disease who may benefit from vitamin E supplementation. Those individuals with the haptoglobin 2/2 variant are at risk for accelerated oxidative damage due to delayed clearance of haptoglobin-hemoglobin complexes. Vitamin E supplementation (400 IU daily) in those individuals has been demonstrated to reduce the risk of CVD events and CVD death.

  • No increased CVD risk other than from risk associated with underlying conditions
  • Genotype 1/1
  • Genotype 1/2
  • 3-Fold increased CVD risk in patients with diabetes or kidney disease1
  • Genotype 2/2


  1. Cahill LE, Levy AP, Chiuve SE, et al. Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin. J Am Coll Cardiol 2013; 61:728–37.

Methodology - Real-time polymerase chain reaction (PCR)

Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL whole blood collected in EDTA (Lavender Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)