Helper Suppressor Ratio, CD4:CD8, Pediatric

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Turnaround Time: 1 - 3 days
CPT Code:


Test Type: 1 mL Whole blood
Stability Time:



Room temperature

2 days





Freeze/thaw cycles



HIV-1 infection results in a decrease of CD4 T cells, an increase of CD8 T cells, a decrease in the CD4:CD8 ratio, and a progressive destruction of immune function. In HIV-1 seropositive patients, enumeration of CD4 T cells may be used for prognostic purposes and to monitor disease progression and antiretroviral therapy. 1997 revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus (HIV). Centers for Disease Control and Prevention. MMWR Recomm Rep.

1997 Jan 10;46(RR-2):1-29. PubMed 9011774

Giorgi J, Kesson A, Chou CC. Immunodeficiency and infectious diseases. In: Rose N, deMacario E, Fahey J, et al, eds. Manual of Clinical Laboratory Immunology. 4th ed. Washington, DC: ASM Press;1992:chap 25.

Stevens RA, Lempicki RA, Natarajan V, et al. General immunologic evaluation of patients with immunodeficiency virus infection. In: Detrick B, Hamilton RG, Folds JD, et al, eds. Manual of Molecular and Clinical Laboratory Immunology. 7th ed. Washington, DC: ASM Press;2006:chap 95.

Collection Details:

Collection Instructions:

State date and time of collection on the test request form. For Pediatric samples.

This assay is currently not available in New York state.

BD EDTA Microtainer, BD EDTA 2.0 mL Vacutainer tube or BD EDTA 4.0 mL Vacutainer tube

Invert tube 8 to 10 times immediately after collection. To preserve cellular viability, collect specimen so it will arrive in the laboratory within 48 hours of collection. Indicate date and time of venipuncture on the tube(s) and on the request form.

Maintain specimen at room temperature.