Hemoglobin (Hb) Solubility With Reflex to Hemoglobin Fractionation, Blood*

Qualitative determination of presence of hemoglobin S; detect sickling hemoglobins; evaluate hemolytic anemia, undiagnosed hereditary anemia with morphologic (sickle-like) abnormalities on peripheral blood smear.

Chehab FF, Kan YW. Detection of sickle cell anaemia mutation by colour DNA amplification. Lancet. 1990 Jan 6; 335(8680):15-17. PubMed 1967329

Miale JB. Laboratory Medicine: Hematology. 6th ed. St Louis, Mo: Mosby-Year Book Inc;1982:624-625.

No preliminary fluid or food restriction is required.