Hepatitis B Surface Antibody, Quantitative, HB Immune Globulin Assessment

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Turnaround Time: 1 - 2 days
CPT Code:


Test Type: 1 mL Serum or plasma
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3


This test is designed for use in assessing therapy with HBIG for patients who have had a liver transplant.

Presence of anti-HBs is not an absolute indicator of resolved hepatitis infection nor of protection from future infection. Since there are different serologic subtypes of hepatitis B virus, it is possible (and has been reported) for a patient to have antibody to one surface antigen type and to be acutely infected with a virus of a different subtype. Thus, a patient may have coexisting HBsAg and anti-HBs. Transfused individuals or hemophiliacs receiving plasma components may have false-positive results for antibody to hepatitis B surface antigen.

Centers for Disease Control and Prevention. Hepatitis B virus: A comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination-Recommendations of the immunization practices advisory committee (ACIP).MMWR. 1991 Nov 22; 40(RR-13):1-25. PubMed 1835756

Devine P, Taswell HF, Moore SB, Gilchrist GS, Jacobson TM. Passively acquired antibody to hepatitis B surface antigen. Pitfall in evaluating immunity to hepatitis B viral infections. Arch Pathol Lab Med. 1989 May; 113(5):529-531. PubMed 2712676

Edwards MS. Hepatitis B serology-help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). PubMed 3287312

Foutch PG, Carey WD, Tabor E, et al. Concomitant hepatitis B surface antigen and antibody in thirteen patients. Ann Intern Med. 1983 Oct; 99(4):460-463. PubMed 6625377

Francis DP, Hadler SC, Thompson SE, et al. The prevention of hepatitis B with vaccine: Report of the Centers for Disease Control Multi-Center Efficacy Trial among homosexual men. Ann Intern Med. 1982 Sep; 97(3):362-366. PubMed 6810736

Lee HS, Vyas GN. Diagnosis of viral hepatitis. Clin Lab Med. 1987 Dec; 7(4):741-757. PubMed 3319367

Protection Against Viral Hepatitis. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Recomm Rep. 1990 Feb 9; 39(RR-2):1-26. PubMed 2153904

Swenson PD, Escobar MR, Carithers RL Jr, Sobieski TJ 3rd. Failure of preexisting antibody against hepatitis B surface antigen to prevent subsequent hepatitis B infection. J Clin Microbiol. 1983 Aug; 18(2):305-309. PubMed 6619284

Collection Details:

Collection Instructions:

Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube.

If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

Room temperature.