Hepatitis Be Antibody (006635)

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Turnaround Time: 1 - 5 days
CPT Code:


Test Type: 1 mL Serum or Plasma
Stability Time:



Room Temperature

7 days (stability provided by manufacturer or literature reference)


7 days (stability provided by manufacturer or literature reference)


14 days (stability provided by manufacturer or literature reference)

Freeze/thaw cycles

Stable x3 (stability provided by manufacturer or literature reference)

Reference Range:



Differential diagnosis, staging, and prognosis of hepatitis B infection.

The appearance of anti-HBe in patients who have previously been HBeAg positive indicates a reduced risk of infectivity. Failure of appearance implies disease activity and probable chronicity but patients with HBeAb may have chronic hepatitis. Chronic HBsAg carriers can be positive for either HBeAg or anti-HBe, but are less infectious when anti-HBe is present. HBe can persist for years, but usually disappears earlier than anti-HBs or anti-HBc. Anti-HBe has not been found as the sole serologic marker for hepatitis B infection.

Bortolotti F, Calzia R, Cadrobbi P, Crivellaro C, Alberti A, Marazzi MG. Long-term evolution of chronic hepatitis B in children with antibody to hepatitis B e antigen. J Pediatr. 1990 Apr; 116(4):552-555. PubMed 2319401

Edwards MS. Hepatitis B serology-help in interpretation. Pediatr Clin North Am. 1988 Jun; 35(3):503-515 (review). PubMed 3287312

Mushahwar IK, Dienstag JL, Polesky HF, McGrath LC, Decker RH, Overby LR. Interpretation of various serological profiles of hepatitis B virus infection. Am J Clin Pathol. 1981 Dec; 76(6):773-777. PubMed 7315794

Mushahwar IK, McGrath LC, Drnec J, Overby LR. Radioimmunoassay for detection of hepatitis B e antigen and its antibody. Results of clinical evaluation. Am J Clin Pathol. 1981 Nov; 76(5):692-697. PubMed 6170222

Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1; 294(14):746-749. PubMed 943694

Collection Details:

Collection Instructions:

Red-top tube, gel-barrier tube, or lavender-top (EDTA) tube.

If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.