High Sensitivity C-Reactive Protein (hs-CRP) (601)

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CPT Code:


Test Type: 1.0 mL Serum or 1.0 mL EDTA Plasma Kit Based
Stability Time:


Refrigerated: 2 months

Reference Range:
  • Optimal: <1.0 mg/L
  • Borderline: 1.0–3.0 mg/L
  • Increased Risk: >3.0 mg/L


CRP is an acute phase inflammatory plasma protein synthesized by the liver. The “high sensitivity” CRP test is needed to detect very low levels of CRP that may be seen with vascular and/or systemic inflammation.




  • hs-CRP may be an independent predictor of developing CVD events and can provide independent prognostic information after initiating treatment.
  • High levels of hs-CRP can also predict cardiovascular events and may be useful in determining how well a patient is responding to lifestyle change and statin treatment.1


  1. Ridker PM, Danielson E, Fonseca FA, et al. JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009;373(9670):1175-1182.

Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)