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Register NowHuman Herpesvirus 6 (HHV-6) Antibodies, IgG
Create a Free Account to View PricesTurnaround Time: 2-6 days
CPT Code:
86790
Test Type: 1 mL Serum
Stability Time:
|
Temperature |
Period |
|---|---|
|
Room temperature |
14 days |
|
Refrigerated |
14 days |
|
Frozen |
14 days |
|
Freeze/thaw cycles |
Stable x4 |
Reference Range:
• Negative: <0.90 index
• Equivocal: 0.90−1.10 index
• Positive: >1.10 index
Fourfold rises in titer are suggestive of either recent, primary, or reactivated infection. The presence of elevated titers to HHV-6 in the absence of responses to HAV, HBV, CMV, and EMV suggests that titer results are associated with high specificity.
Overview:
Aid in the diagnosis of past infection/exposure to roseola infantum; may be useful in diagnosis of chronic fatigue syndrome This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients. Human herpesvirus 6 (HHV-6) has recently been identified as the agent associated with both pediatric and adult infections. Most children have been infected by age three. The acute infection in children is characterized clinically by an acute febrile illness, irritability, inflammation of tympanic membranes, and (uncommonly) a rash characteristic of roseola. In adults, HHV-6 has been associated with chronic fatigue and spontaneously resolving fever resembling a mononucleosis-like illness. During the acute episode an elevated IgM HHV-6 is useful. An increase in IgG HHV-6 between acute and convalescent serum sample is consistent with a recent HHV-6 infection.
Huang LM, Lee CY, Lin KH, et al. Human herpesvirus-6 associated with fatal haemophagocytic syndrome. Lancet. 1990 Jul 7; 336(8706):60-61. (letter) PubMed 1973248
Suga S, Yoshikawa T, Asano Y, Yazaki T, Hirata S. Human herpesvirus-6 infection (exanthem subitum) without rash. Pediatrics. 1989 Jun; 83(6):1003-1006. PubMed 2542875
Wakefield D, Lloyd A, Dwyer J, Salahuddin SZ, Ablashi DV. Human herpesvirus-6 and myalgic encephalomyelitis. Lancet. 1988 May 7; 1(8593):1059. PubMed 2896906
Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet. 1988 May 14; 1(8594):1065-1067. PubMed 2896909
Collection Details:
Collection Instructions:
Red-top tube or gel-barrier tube.
Specimen should be free of bacterial contamination, hemolysis, and lipemia.
Room temperature.