Immunoglobulin A (IgA), Quantitative

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Category:

Turnaround Time: Within 1 day
CPT Code: 82784
Test Type: 1 mL (adult), 0.4 mL (pediatric) Serum
Stability Time:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3
Reference Range:

Immunoglobulin A, Quantitative

 

Age

Range (mg/dL)

Male

0 to 10 d

2−362

11 d to 6 m

8−37

7 to 11 m

12−58

1 to 3 y

21−111

4 to 15 y

52−221

16 to 60 y

90−386

>60 y

61−437

Female

0 to 10 d

2−362

11 d to 6 m

8−32

7 to 11 m

11−45

1 to 3 y

19−102

4 to 15 y

51−220

16 to 70 y

87−352

>70 y

64−422

Overview:

Evaluate humoral immunity; monitor therapy in IgA myeloma.

If samples containing macroglobulins, cryoglobulins, or cold agglutinins are handled at incorrect temperatures, false low values may result.

Increased monoclonal IgA may be produced in lymphoproliferative disorders, especially multiple myeloma and “Mediterranean” lymphoma involving bowel. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG2 and IgG4. IgA may be decreased in patients with chronic sinopulmonary disease, in ataxia-telangiectasia, or congenitally. Patients with congenital IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA and anaphylaxis if transfused. IgA levels may rise with exercise and fall during pregnancy.     

Collection Details:

Collection Instructions:

Indicate the patient's age on the test request form.

Red-top tube or gel-barrier tube.

Samples suspected of having macroglobulins or cryoglobulins should be drawn and held at 37°C. Samples suspected of containing cold agglutinins should not be refrigerated prior to serum separation from clot.