Immunoglobulin E (IgE), Total

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Category:

Turnaround Time: 2 - 4 days
CPT Code:

82785

Test Type: 0.8 mL Serum
Stability Time:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x3

Reference Range:

Age

Male

Female

1 to 30 days

Not established

Not established

1 to 5 months

1 – 30

1 – 16

6 months

2 – 52

1 – 24

7 to 11 months

2 – 82

2 – 82

1 year

3 – 200

2 – 100

2 to 3 years

6 – 366

4 – 227

4 to 6 years

14 – 710

6 – 455

7 to 9 years

19 – 893

12 – 708

10 years

22 – 1055

12 – 708

11 years

22 – 1055

12 – 796

12 years

16 – 810

12 – 796

13 years

19 – 893

9 – 681

14 to 15 years

20 – 798

6 – 681

16 years

18 – 628

9 – 472

17 to 100 years

6 – 495

6 – 495

Overview:

Evaluate immunoglobulin status in possible atopic disease.

Normal IgE levels do not exclude allergic phenomena.

The concentration of IgE in serum of normal individuals typically represents <0.001% of the total immunoglobulins present.1,2 Immunoglobulins of the IgE class play an important role in mediating the atopic reactions that occur when sensitive individuals are exposed to allergens. IgE has a structure that is similar to other immunoglobulins in that it consists of four chains: two light chains and two heavy chains.1 The heavy chains for each IgE molecule contain a variable region that accounts for antigen specificity. Since IgE myeloma is extremely rare, the clinical utility of measuring IgE levels generally involves its role as the mediator of the allergic response. The majority of IgE molecules in serum are bound to the surface of mast cells and basophilic granulocytes. The interaction of allergens with the cell-bound allergen-specific IgE causes these cells to release histamines and other vasoactive substances, thereby initiating the allergic reaction. Approximately 50% of individuals with allergic rhinitis or asthma will have elevated levels of IgE;1 however, a large number of individuals with allergy and elevated levels of IgE to specific allergens will have normal levels of total IgE. Studies have indicated that total IgE levels are often elevated in patients with atopic dermatitis and the concentration of IgE tends to correlate with severity of eczema.1 Total IgE levels can also be elevated in patients with parasitic infections, allergic bronchopulmonary aspergillosis, or immunodeficiency.1,2

1. Dolen WK. The diagnostic allergy laboratory. In: Rose NR, Hamilton RG, Detrick B, eds. Manual of Clinical Laboratory Immunology. 6th ed. Washington, DC: ASM Press; 2002:883-890.

2. Zeiss RC, Pruzansky JJ. Immunology of IgE-mediated and other hypersensitivity states. In Grammar LC, Greenberger PA, eds. Patterson's Allergic Diseases. 6th ed. Hagerstown, Md: Lippincott Williams and Wilkins;2002:43-54.

Collection Details:

Collection Instructions:

Red-tube or gel-barrier tube.

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Room temperature.