Interleukin-04 (IL-4), Serum

Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T lymphocytes, CD3+ cells, NK-T cells, mast cells, eosinophils, and basophils.¹ IL-4 has multiple immune response modulation functions on a variety of cell types. It is an important regulator of isotype switching, inducing IgE production in B lymphocytes. It is an important modulator of the differentiation of precursor T helper cells to the TH2 subset that mediates humoral immunity and modulates antibody production. In addition, IL-4 has also been shown to have antitumor activity both in vivo and in vitro.¹

Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

1. Okada H, Banchereau J, Lotze MT. Interleukin-4. In: Thomson AW, Lotze MT, eds. Cytokine Handbook. Vol 1, 4th ed. San Diego, Calif: Academic Press; 2003: 227-262.