Interleukin-10 (IL-10), Serum

Interleukin-10 (IL-10) is an important suppressor of immune responses.1-3 In vitro studies indicate that IL-10 directly inhibits IL-2 and IL-5 production by TH1 and TH2 cells. IL-10 acts as an immunosuppressor of antigen presenting cells (APC). IL-10 suppresses epidermal Langerhans cell APC function, monocyte chemokines expression, and the bactericidal responses of macrophages. A number of studies suggest that IL-10 plays a role in controlling inflammation, autoimmunity, and angiogenesis.

Results of this test are for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

1. Ding UZ, Fu S, Zamarin D, et al. Interleukin-10. In: Thomson AW, Lotze MT eds. Cytokine Handbook. 4th ed, vol 1. London, UK, and San Diego, Calif: Academic Press, Elsevier Science;2003:603-625.

2. Mosser DM, Zhang X. Interleukin-10: New perspectives on an old cytokine. Immunol Rev. 2008 Dec; 226:205-218. PubMed 19161426

3. Hedrich CM, Bream JH. Cell type-specific regulation of IL-10 expression In inflammation and disease. Immunol Res. 2010 Jul; 47(1-3):185-206. PubMed 20087682