Iodine, Urine With Creatinine Ratio

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Turnaround Time: 2 - 4 days
CPT Code:

83789, 82570

Test Type: 15 mL Urine
Stability Time:



Room temperature

7 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

29.0−536.0 μg/g


Monitor exposure to iodine; evaluate for iodine deficiency disorders (IDDs), excessive iodine intake, or iodine in the workplace.

Iodine Deficiency Disorders by Age Group1

Age Groups

Health Consequences of Iodine Deficiency

All ages


Increased susceptibility of thyroid gland to nuclear radiation




Congenital anomalies

Perinatal mortality


Infant mortality

Endemic cretinism

Children and adolescents

Impaired mental function

Delayed physical development


Impaired mental function

Reduced work productivity

Toxic nodular goiter; iodine-induced hyperthyroidism

Increased occurrence of hypothyroidism in moderate-to-severe iodine deficiency; decreased occurrence of hypothyroidism in mild-to-moderate iodine deficiency

Other forms of thyroid problems, namely iodine-induced hypothyroidism, autoimmune thyroiditis, and hyperthyroidism associated with excessive iodine intake, have become a greater concern than deficiency disorders.2

1. Zimmermann MB. Iodine deficiency. Endocr Rev. 2009 Jun; 30(4):376-408. PubMed 19460960
2. Hollowell JG, Staehling NW, Hannon WH, et al. Iodine nutrition in the United States, trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab. 1998 Oct; 83(10):3401-3408. PubMed 9768638





Collection Details:

Collection Instructions:

If 24-hour urine is submitted, the test request form must state 24-hour collection volume.

Plastic urine container without preservative.

Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely. Transport the specimen promptly to the laboratory. Container must be labeled with the patient's full name, room number, the date and time collection started, and the date and time collection finished. Do not use preservative.

Maintain specimen at room temperature.