Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) (602)

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CPT Code:


Test Type: 1.0 mL Serum Kit Based
Stability Time:


Refrigerated: 14 days

Reference Range:
  • Optimal:  <180 nmol/min/mL
  • Borderline: 180-224 nmol/min/mL
  • Increased Risk: ≥225 nmol/min/mL


LpPLA2 is an enzyme produced by monocytes/macrophages that breaks down phospholipids. Increased blood levels of LpPLA2 are associated with soft, active growing plaque.*

*NOTE: Soft plaque is not stable calcified plaque.


Enzyme Colormetric


Predicts CVD risk independent of LDL-C and other inflammatory markers.1 Associated with:

  • 2-fold increased risk for coronary events
  • 2-fold increased risk for stroke


  1. Davidson MH, Corson MA, Alberts MJ, et al. Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines. Am J Cardiol. 2008;101(Suppl):51F-57F.


Collection Details:

Collection Instructions:

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)


Transport Temperature

Refrigerated (ship on frozen cold packs)