Measles, Mumps, Rubella (MMR) Immunity Profile

Overview:

Aid in the determination of serological status to measles, mumps, and rubella viruses. A positive result generally indicates exposure to virus or previous vaccination. A positive result is considered adequate laboratory evidence of immunity.

Measles

Acceptable presumptive evidence of Measles Immunity (at least one of the following):

- Documentation of age-appropriate vaccination against measles virus.

- Laboratory evidence of immunity (IgG in serum; equivocal results should be considered negative).

- Laboratory confirmation of measles.

- Birth before 1957.

Persons who have measles-specific IgG antibody that is detectable by any commonly used serological assay are considered to have adequate laboratory evidence of measles immunity. Persons with an equivocal serologic test result do not have adequate presumptive evidence of immunity and should be considered susceptible unless they have other evidence of measles immunity.

Documented age-appropriate vaccination supersedes the results of subsequent serologic testing. If a person who has two documented doses of measles-containing vaccine is tested serologically and is determined to have negative or equivocal measles results, it is not recommended that the person receive an additional dose of vaccine. Such persons should be considered to have presumptive evidence of immunity.

Mumps

Acceptable presumptive evidence of Mumps Immunity (at least one of the following):

- Documentation of age-appropriate vaccination against mumps virus.

- Laboratory evidence of immunity (IgG in serum; equivocal results should be considered negative).

- Laboratory confirmation of disease.

- Born before 1957.

Rubella

Acceptable presumptive evidence of Rubella Immunity (at least one of the following):

- Documentation of 1-dose of live rubela virus-containing vaccine.

- Laboratory evidence of immunity (IgG in serum; equivocal results should be considered negative).

- Laboratory confirmation of disease.

- Born before 1957 (except women of childbearing age who could become pregnant).

Centers for Disease Control and Prevention. Manual for the Surveillance of Vaccine-Preventable Diseases. CDC web site. https://www.cdc.gov/vaccines/pubs/surv-manual/index.html. Accessed June 2019.

Centers for DIsease Control and Prevention. Measles (Rubeola): For Healthcare Professionals. CDC web site. https://www.cdc.gov/measles/hcp/. Accessed June 2019.

McLean HQ, Fiebelkorn AP, Temte JL, Wallace GS; Centers for Disease Control and Prevention. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2013 Jun 14;62(RR-04):1-34. PubMed 23760231