Monkeypox (Orthopoxvirus), DNA, PCR (Available for draw in office only)

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Turnaround Time: 2-3 days
CPT Code:


Test Type: Lesion Swab
Stability Time:

Refrigerated 7 days


***This test is only available for clients that collect specimens in-office, not available at LabCorp Patient Service Centers***

Use: Vesicular specimens collected from persons infected with a non-variola Orthopoxvirus (such as vaccinia, monkeypox, or cowpox) are expected to produce a positive result with this assay. Although this assay does not differentiate vaccinia or monkeypox virus from cowpox, camelpox, ectromelia or gerbilpox virus, a positive result with this assay in the United States is most likely due to monkeypox virus or vaccinia virus; however, potential exposure to other Orthopoxviruses should be considered.

Limitations: A false negative result may occur if a sample is improperly collected, transported or handled. False-negative results may occur if the quantity of viral DNA present in the sample is below the limit of detection for the assay. An inconclusive result may be returned if the lesion is not adequately sampled.

Methodology: Polymerase chain reaction (PCR)

Additional Information: If monkeypox is suspected, do not submit specimens for any Viral Cultures. Testing for HSV and VZV by molecular methods is available. See Herpes Simplex Virus (HSV) and Varicella Zoster Virus (VZV) Profile (Lesions), PCR [139367] for further information.

Collection Details:

Collection Instructions:

Specimen: Lesion swab

Volume: One swab in UTM or VTM

Container: Universal Transport Media (UTM) or Viral Transport Media (VTM)

Collection: Vigorously swab or brush the base of the lesion with a sterile dry polyester, rayon or Dacron swab. Insert the swab into the tube containing UTM or VTM. Carefully break the swab at the scoreline and tightly close the sample. Some UTM kits may contain two swabs; however, only one swab needs to be collected and submitted for testing. If multiple lesions with differing appearances are present, consider submitting an additional UTM/VTM collection, as described above, for each lesion.

Storage Instructions: Refrigerate.

Causes for Rejection: Improperly submitted specimens, including grossly leaking samples; swabs submitted in non-validated transport media, including 0.9% saline or liquid Amies (E-Swabs); swab specimens submitted in aerobic or anaerobic transport devices.