Natural Killer Cell and Activated T-Cell Profile/IL-2r

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Category:

Turnaround Time: 1 - 3 days
CPT Code:

86357, 86359, 86356

Test Type: Whole blood, fill tube(s) to capacity
Stability Time:

Temperature

Period

Room temperature

2 days

Refrigerated

Unstable

Frozen

Unstable

Freeze/thaw cycles

Unstable
Reference Range:

Reference intervals for adults have been established by the laboratory. See table.

Adult Reference Intervals for Lymphocyte Immunophenotyping

 

CD

95% Confidence Interval

Percentage

Cells/mm3

Minimum

Maximum

Minimum

Maximum

CD3+

58

86

622

2402

CD3+CD25+

5

26

79

535

CD3-CD56+

1

19

24

406

Overview:

Assess changes in T-lymphocyte surface markers that may indicate immune stimulation.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Natural killer (NK) cells are large granular lymphocytes that mediate MHC-unrestricted cytotoxicity against virus-infected and malignant cells and manufacture a number of cytokines following stimulation of the immune system.

The combination of IL-2 and T-cell markers can be used to assess the state of activation of T cells. NK cells are responsible for the destruction of virally infected cells, tumor cells, and antibody-dependent cellular cytotoxicity.

Caligiuri M, Murray C, Buchwald D, et al. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol. 1987 Nov 15; 139(10):3306-3313. PubMed 2824604

Landay AL, Jessop C, Lennette ET, Levy JA. Chronic fatigue syndrome: Clinical condition associated with immune activation. Lancet. 1991 Sep 21; 338(8769):707-712. PubMed 1679864

Lanier L, Jackson A. Monoclonal antibodies: Differentiation antigens expressed on leukocytes. In: Rose N, deMacario E, Fahey J, et al, eds. Manual of Clinical Laboratory Immunology. 4th ed.

Collection Details:

Collection Instructions:

Lavender-top (EDTA) tube and yellow-top (ACD-A) or (ACD-B) tube

Invert tube 8 to 10 times immediately after collection. To preserve cellular viability, collect specimen so it will arrive in the laboratory within 48 hours of collection. Indicate date and time of venipuncture on the tube(s) and on the test request form.

Maintain specimen at room temperature.