Organic Acids Test (OAT) - Urine

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Category:

Turnaround Time: 1 - 2 weeks
CPT Code: 82131, 82507, 82570, 83150, 83497, 83605, 83921*66, 83945, 84207, 84210, 84585
Test Type: Kit Based, Urine
Stability Time:

7 days refrigerated and 6 months frozen

Overview:

Organic acids are products of the body?s metabolic pathways. Evaluation of these downstream metabolites from various metabolic pathways provides insight into important areas related to gut health, mitochondrial dysfunction, neurotransmitter status, indicators of detoxification and macronutrient breakdown and nutritional status. This makes organic acid testing a valuable tool to assess the functional need for essential nutrients, diet modification, antioxidant protection, detoxification, and other therapies. The Organic Acids Test (OAT) provides a comprehensive nutritional and metabolic snapshot of an individual?s overall health. The OAT measures 76 organic acids from one easy to collect urine sample. Why Run an Organic Acids Test (OAT)? The Organic Acids Test (OAT) is a simple and efficient way to assess a number of metabolic pathways providing insight into imbalances and nutrient needs. The OAT can provide insight into a wide range of conditions, making it valuable for individuals who are experiencing complex chronic conditions. The OAT test report is organized into clinically useful categories including: Intestinal Microbial Overgrowth markers evaluate for candida activity, clostridia bacteria toxins, potential mold exposure, and imbalance in the gut microflora. Oxalate Metabolites provide insight into oxalate levels being generated by organisms within the system or via dietary contributions. Glycolytic Cycle Metabolites and Mitochondrial Markers (Krebs Cycle and Amino Acid Metabolites) evaluate for metabolic efficiency (e.g., use of glucose and amino acids for energy generation) and mitochondrial dysfunction. Neurotransmitter Metabolites evaluate for phenylalanine, tyrosine and tryptophan metabolism which are linked to neurotransmitter status and quinolinic acid production. Pyrimidine Metabolites & Ketone and Fatty Acid Oxidation markers give insight into folate status and cellular turnover, as well as mitochondrial utilization of fatty acids for energy production. Nutritional Markers provide insight into the sufficiency of essential vitamins, antioxidants, and metabolic pathway co-factors. Indicators of Detoxification assess for the presence of oxidative stress via markers of glutathione sufficiency and methylation versus transsulfuration function. Amino Acid Metabolites may suggest functional nutrient need or be reflective of genetic metabolic dysfunction if a consistently, persistently elevated level of a particular analyte is noted. The Mineral Metabolism marker provides insight into dietary intake of phosphate and can give insights into Vitamin D levels.

Collection Details:

Patient Preparation:

Wait 48 hour after completing a course of antibiotics before collection. Avoid the following foods for 48 hours prior to collecting your specimen as they may interfere with the test outcome: Apples, apple juice and products, Grapes, grape juice and products (including raisins) , Pears, pear juice and products, Cranberries, cranberry juice and products, Reishi Mushrooms, Echinacea, Arabinogalactan, or Ribose Supplements. mportant: Do not discontinue any medications or supplements without first consulting your healthcare practitioner.

Collection Instructions:

Preparing For Your Test ? Plan now to collect your sample first thing in the morning, and early in the week. For US collections, collect your ?first morning sample? on a Monday-Thursday morning. Outside the US, the sample should be collected on Monday or Tuesday to allow extra time for shipping. ? Collect your first urine specimen in the morning before eating or drinking. This is the most concentrated collection. ? Avoid contamination of samples with blood or while menstruating as this may interfere with test results. Wait until the following week. ? Place the Collection Cup and these instructions in the bathroom where you plan to collect the samples in the morning. Set the rest of the contents aside. ? Place the ice pack flat in your freezer, so it will be ready to ship with your specimen. ? Pediatric collection bags are available upon request for children not potty trained to aid with collection. Collection Day Instructions: ?Look at the volume markings on the side of the collection cup. You will need a minimum of 10 mL for each test on the order. ?Verify how many tests have been ordered, so you know how much sample to collect. ?Collect your first morning urine sample in the provided collection cup. DO NOT eat or drink prior to collecting your sample. Please collect at least the minimum amount of urine required for the number. of tests on your order. Collecting more than the minimum is recommended, but not required. Pour off anything above 50 mL indicator line to prevent leaking once frozen. ?Locate and complete the barcode sheet in your test kit. Place one barcode sticker on each collection sample. Be sure that the information is legible and includes the collection date, time, and that the name matches what was provided on the test order. After You Collect: ? Fill any other vials that have been included for other urine tests. Follow the instructions in those test kits for collections.? Place the lid on the collection cup and seal tightly. ? Ensure each sample has the completed barcode sticker. ? Place the collection cup in your freezer for at least four hours or until frozen (30 days maximum). Check the box on the barcode label to indicate that the sample has been frozen. ? Ensure all samples are labeled. Unlabeled samples will be rejected. Packaging the shipment: ?Retrieve the packaging material you set aside. Locate the clear biohazard zip-lock bag, silver thermo bag, and absorbent packing sheet. ?Remove the frozen collection cup, frozen ice pack, and any vials for other urine tests from the freezer and check caps for tightness. ?Place all frozen specimens and absorbent packing sheet in the biohazard zip-lock bag and seal. ?Place the sealed biohazard zip-lock bag into the silver thermo bag along with the frozen ice pack. ?Place the filled silver thermo bag into the box. If using the Test Requisition Form, also place in box. Close the lid. Locate the shipping instruction card included in your test kit for details on how to ship your collection(s)