Phosphorylated Tau 181 (pTau-181), Plasma (483745)

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Turnaround Time: 1 -3 Days
CPT Code:

835250

Test Type: 1 mL EDTA Plasma, Room Temperature

Overview:

Use: This test is used for the measurement of the level of Phosphorylated Tau 181 (pTau-181) in plasma.

Limitations: This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

This test is performed by Roche Diagnostics Electrochemiluminescence Immunoassay (ECLIA). Values obtained with different assay methods or kits cannot be used interchangeably.

Hepatic and renal function impact concentrations of pTau-181.1,2

Results of plasma pTau-181 testing in patients with a history of myocardial infarction (MI) or clinical stroke should be interpreted with caution.2

Methodology: Roche Diagnostics Electrochemiluminescence Immunoassay (ECLIA)

Reference Interval
• 0 - 55 years: 0.00–0.95 pg/mL

Reference interval is based on a population of ostensibly healthy individuals aged 20 to 55 years. Test performed by Roche Diagnostics Electrochemiluminescence Immunoassay (ECLIA). Values obtained with different methods cannot be used interchangeably.

• >55 years: 0.00–0.97 pg/mL

Results greater than the clinical cut-off of 0.97 pg/mL in patients greater than 55 years of age are correlated with Abeta amyloid pathology as determined by amyloid PET imaging. Test performed by Roche Diagnostics Electrochemiluminescence Immunoassay (ECLIA). Values obtained with different methods cannot be used interchangeable.

Collection Details:

Collection Instructions:

Specimen: EDTA plasma

Volume: 1 mL

Minimum Volume: 0.7 mL (Note: This volume does not allow for repeat testing.)

Container: Lavender-top (EDTA) tube

Collection: Draw blood in a lavender-top (EDTA) tube. Invert to mix with preservatives. Centrifuge and transfer plasma to a labeled plastic transport tube.

Storage Instructions: Room temperature