Protein and Creatinine, Random Urine

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Turnaround Time: Within 1 day
CPT Code:

82570, 84156

Test Type: 50 mL Urine (random)
Stability Time:



Room temperature

7 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

Protein/Creat Ratio 1mg/g 0 - 200


Protein:creatinine ratio in a first-morning or random untimed "spot" urine specimen is recommended testing to ascertain chronic kidney disease.1 It is also used to evaluate nephrotic syndromes; work up other renal diseases, including malignant hypertension, glomerulonephritis, Goodpasture syndrome, cryoglobulinemia, toxemia of pregnancy, drug nephrotoxicity, and renal tubular lesions; manage myeloma and macroglobulinemia of Waldenström (Bence Jones proteinuria); evaluate hypoproteinemia; tubular proteinurias, including Wilson's disease and Fanconi syndrome. Albumin/Creatinine Ratio, Random Urine is a more sensitive marker of progression and regression of renal disease than urine total protein, especially when urine total protein is <300 mg/g creatinine.

1. Kidney Disease Outcomes Quality Initiative (K/DOQI). K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease.Am J Kidney Dis. 2004 May; 43(5 Suppl 1):S1-290. PubMed 15114537

Collection Details:

Collection Instructions:

Plastic urine container, no preservative.

Collect random urine in a clean plastic container. Label the urine container with the patient's full name and the date and time of collection.

Room temperature.