Tissue Transglutaminase (tTG), IgA

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Turnaround Time: 1-3 days
CPT Code:


Test Type: 1 mL Serum
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

• Negative: 0−3 units/mL

• Weak positive: 4−10 units/mL

• Positive: >10 units/mL


Detection of antibodies to aid in the diagnosis of gluten-sensitive enteropathy (GSE), such as celiac disease and dermatitis herpetiformis.

A negative tTG IgA result in an untreated patient does not rule out gluten-sensitive enteropathy. This result can often be explained by selective IgA deficiency, a relatively frequent finding in celiac disease. Results of this assay should be used in conjunction with clinical findings and other serological tests.

Studies have demonstrated that IgA endomysial antibody tests have >99% specificity for gluten-sensitive enteropathy.1 Recently, the endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase (tTG).2

1. Volta U, Molinaro N, De Franchis R, et al. Correlation between IgA antiendomysial antibodies and subtotal villous atrophy in dermatitis herpetiformis. J Clin Gastroenterol. 1992 Jun; 14(4):298-301. PubMed 1607605

2. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul; 3(7):797-801. PubMed 9212111

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Room temperature.