Tissue Transglutaminase (tTG), IgG

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Turnaround Time: 1-3 days
CPT Code:


Test Type: 1 mL Serum
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

• Negative: <6 units/mL

• Weak positive: 6−9 units/mL

• Positive: >9 units/mL


Detection of antibodies to aid in the diagnosis of gluten-sensitive enteropathy (GSE), such as celiac disease and dermatitis herpetiformis.

A negative result does not rule out celiac disease. The inclusion of the tTG IgG autoantibodies is important because it is not uncommon for celiac patients to be IgA deficient. Results of this assay should be used in conjunction with clinical findings and other serological tests.

Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul; 3(7):797-801. PubMed 9212111

Volta U, Molinaro N, De Franchis R, et al. Correlation between IgA antiendomysial antibodies and subtotal villous atrophy in dermatitis herpetiformis. J Clin Gastroenterol. 1992 Jun; 14(4):298-301. PubMed 1607605

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Room temperature.