Vitamin K1 (Phylloquinone / Phytonadione)

Vitamin K deficiency may be induced by obstructive liver disease, obstructive icterus, malabsorption due to celiac disease, pancreatitis, diarrhea, and antibiotic abuse; may be used to treat blood clotting disorders, bone metabolism disorders, and hemorrhagic disorders of newborns.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

In humans, deficiency of vitamin K leads to decreased concentrations of circulating, active coagulation factors, which often results in bleeding. Vitamin K nutritional status has also been implicated in osteoporosis. Interest in vitamin K has increased beyond its well-established function in blood clotting with human epidemiological and intervention studies suggesting that vitamin K may reduce bone loss in osteoporotic people and decrease fracture risk.

Bovill EG, Soll RF, Lynch M, et al. Vitamin K1 metabolism and the production of des-carboxy prothrombin and protein C in the term and premature neonate. Blood. 1993 Jan 1; 81(1):77-83. PubMed 8417804

Haroon Y, Bacon DS, Sadowski JA. Liquid-chromatographic determination of vitamin K1 in plasma, with fluorometric detection. Clin Chem. 1986 Oct; 32(10):1925-1929. PubMed 3757212

Wang LY, Bates CJ, Yan L, Harrington DJ, Shearer MJ, Prentice A. Determination of phylloquinone (vitamin K1) in plasma and serum by HPLC with fluorescence detection. Clin Chim Acta. 2004 Sep; 347(1-2):199-207. PubMed 15313159