Vitamin K1 (Phylloquinone / Phytonadione)

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Turnaround Time: 4 - 6 days
CPT Code:


Test Type: 1.5 mL Serum or plasma, frozen
Reference Range:


• 0 to 1 year: 0.13−3.37 ng/mL

• 2 to 17 years: 0.13−1.39 ng/mL

• >17 years: 0.13−1.88 ng/mL


Vitamin K deficiency may be induced by obstructive liver disease, obstructive icterus, malabsorption due to celiac disease, pancreatitis, diarrhea, and antibiotic abuse; may be used to treat blood clotting disorders, bone metabolism disorders, and hemorrhagic disorders of newborns.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

In humans, deficiency of vitamin K leads to decreased concentrations of circulating, active coagulation factors, which often results in bleeding. Vitamin K nutritional status has also been implicated in osteoporosis. Interest in vitamin K has increased beyond its well-established function in blood clotting with human epidemiological and intervention studies suggesting that vitamin K may reduce bone loss in osteoporotic people and decrease fracture risk.

Bovill EG, Soll RF, Lynch M, et al. Vitamin K1 metabolism and the production of des-carboxy prothrombin and protein C in the term and premature neonate. Blood. 1993 Jan 1; 81(1):77-83. PubMed 8417804

Haroon Y, Bacon DS, Sadowski JA. Liquid-chromatographic determination of vitamin K1 in plasma, with fluorometric detection. Clin Chem. 1986 Oct; 32(10):1925-1929. PubMed 3757212

Wang LY, Bates CJ, Yan L, Harrington DJ, Shearer MJ, Prentice A. Determination of phylloquinone (vitamin K1) in plasma and serum by HPLC with fluorescence detection. Clin Chim Acta. 2004 Sep; 347(1-2):199-207. PubMed 15313159

Collection Details:

Collection Instructions:

Lavender-top (EDTA) tube, red-top tube without anticoagulant, or amber plastic transport tube with amber top. (If amber tubes are unavailable, cover standard transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the container and on the outside of the aluminum foil. Secure with tape.) For amber plastic transport tube and amber-top, order LabCorp N° 23598.

Draw blood in chilled lavender-top tubes containing EDTA or in chilled red-top tubes with no anticoagulant. Gently invert five to six times to mix if using anticoagulant tube. Keep unopened vacuum tube on ice before processing. Immediately separate plasma/serum from red cells using refrigerated centrifugation or prechilled centrifuge carrier tubes before centrifuging. Serum or plasma must be separated from cells within 45 minutes of venipuncture. Transfer serum or plasma specimen to a labeled amber transport tube and freeze on dry ice. Protect from light. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Freeze serum or plasma on dry ice in plastic amber transport tube with amber top. Not stable refrigerated. Protect from light. Stable for three months at -20°C.