AgingSOS™ Best Value Panel

Overview:

Maximize your healthspan

Many factors can influence your healthspan and your response to medical treatment for diseases. Some of these factors are genes that you inherit from your parents that do not change over your lifetime. However, the expression of your genes are constantly altered by many other factors inside and outside of your body. These factors, which can be called non-genetic, extrinsic, environmental, or modifiable factors, are most important in determining your healthspan.

Modifiable factors for health and longevity

While your DNA is the master code for your health and longevity, there are many factors that affect how you age: what you eat and drink, how much and when you eat, how much you exercise, how much and how well you sleep, how much stress you experience, whether you are exposed to pollution, radiation, UV rays, toxins, infections, and many other environmental risks. These factors have a huge impact on your health, but you are in control of them and your healthspan.

Interplay between genes and modifiable factors

Our health is determined by the interplay between our unique genetic makeup and our modifiable factors. This dynamic interplay results in a cascade of molecular, cellular and physiological changes, which determine our health, our response to treatment for our diseases and ultimately our longevity. These dynamic changes can be monitored using laboratory tests that measure biomarkers - meaningful signals about our health.

What AgingSOS™ measures

AgingSOS™ are specially designed biomarker panels that measure molecular and cellular functions that are altered with age and predispose aging persons to higher risks of developing age-related diseases such as cancer, diabetes, cardiovascular, renal, neurological, COVID-19 and other infectious diseases.

Aging biomarkers can tell you your wellness status, whether you need to, and how you can, intervene to slow down your aging process and reduce your risks of developing age-related diseases to maximize your healthspan and lifespan. AgingSOS™ measures molecular and cellular functions as well as modifiable factors in six key categories that are important to aging and age-related diseases:

• Chronic inflammation
• Cellular senescence
• Oxidative stress and antioxidant capacity
• Protein glycation
• Tissue stress and damage
• Micronutrients

What AgingSOS™ tells you

• Your overall wellness status, measured by our proprietary W-Index™.
• Whether you are at increased risk of developing age-related diseases.
• Potential solutions to improve your wellness and reduce your disease risk via lifestyle changes and nutritional supplementation.
• Whether you are taking the right kind and the right amount of nutritional supplements.
• Whether your nutritional supplements are providing the desired health benefits.
• How you can potentially improve management of your age-related diseases through nutritional supplements.

Health improvements guided by AgingSOS™

Many middle-aged and senior people, some young adolescents and even young children do have deficiencies or abnormalities that can be revealed by the AgingSOS™ biomarker panels. Many of us take some nutritional supplements with the hope to improve health, reduce risks for illness, and/or increase longevity. However, no one knows what each person really needs the most and whether the supplements are effective.

AgingSOS™ helps you identify the deficiencies and abnormalities that you need to act upon the most. Its biomarkers are actionable, meaning you can take concrete steps now to correct your deficiencies. These actions include lifestyle changes such as more exercise, more sleep, diet, and biomarker-guided supplementation of nutrients that you cannot get enough from your regular foods.

AgingSOS™ allows you to assess the progress you are going to make by retaking the test after concrete actions have been taken. Initiation of actions is a great first step towards your health and longevity while monitoring your progress or lack of progress by retaking the test on a regular interval is even more critical for your long-term health and your longevity. We will recommend the most appropriate time interval for you to retake the test based on your biomarker profile.

AgingSOS™ testing methodology

Most biomarkers in the AgingSOS™ panels are tested using reagents approved by the federal drug administration (FDA) or the Commission of Europe (CE), while other biomarkers are laboratory-developed tests (LDT) that are thoroughly validated for their reproducibility. Client samples are always run contemporaneously with quality control samples on state-of-the-art laboratory equipment for maximum accuracy. However, all tests have a certain degree of variation, and test values at the lower end may be more variable.

Interpretation of AgingSOS™ results

Test results are reported along with the best available ranges in healthy people, thus enabling meaningful assessment of baselines. Interpretation of testing results are based on data from appropriate patients with relevant diseases. In general, the results are put in four categories with color codes: normal/optimum (green), slightly deficient/elevated (yellow), moderately deficient/elevated (orange) or highly deficient/elevated (red).

The overall health/wellness is measured by our proprietary wellness index (W-Index™). Calculation of W-Index™ is based on our proprietary formula derived from artificial intelligence analysis with our extensive database on healthy and diseased subjects.

The best W-Index™ is 100 points and each biomarker deficiency/elevation would deduct a specific number of points based on the degree of deficiency/elevation. A person with a W-Index™ of 55 points or less is considered to have suboptimal health or subhealth, which may be a risk factor of many age-related chronic diseases.

It should be noted that the W-Index™ is calculated based on the tested biomarkers and may be significantly modified by other health information such as diagnosis of diseases or biomarkers that are not measured with the AgingSOS™ panels. It is important that you verify your health information that you provided to us during activation of your test kit and that are summarized at the end of this report as an Appendix. We will generate a new report for you if you update your health information.

The determination of individual biomarker categories as well as the W-Index™ is based on our current knowledge about these biomarkers and is an evolving process as new data continue to accumulate. When significant improvement occurs, your report will be updated on our website. Since you will not be automatically notified of such changes, you may want to periodically check for any potential updates on your report.