Antiextractable Nuclear Antigens (Anti-RNP / Anti-Sm)

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Turnaround Time: 1 - 2 days
CPT Code:


Test Type: 1 mL Serum
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

0.0-0.9 AI


Detect antibodies associated with SLE and mixed connective tissue disease. Anti-Sm is highly specific for SLE. Anti-RNP is found with a variety of rheumatoid diseases with high titers associated mainly with MCTD.

Antibodies that produce a speckled ANA pattern are usually directed against extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells. Included in this group of antigens are RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1.

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Room Temperature.