Antiscleroderma - 70 Antibodies

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Turnaround Time: 1 - 3 days
CPT Code:


Test Type: 1 mL Serum
Stability Time:



Room temperature

14 days


14 days


14 days

Freeze/thaw cycles

Stable x3

Reference Range:

0.0-0.9 AI


Differential diagnosis of scleroderma (progressive systemic sclerosis).

Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Room temperature.