Apolipoprotein A-1

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Category:

Turnaround Time: 1 - 2 days
CPT Code:

82172

Test Type: 2 mL Serum (preferred) or plasma
Stability Time:

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3
Reference Range:

 

Male (mg/dL)

0 to 14 d

62−91

15 d to 11 m

53−175

1 to 5 y

80−164

6 to 12 y

107−175

>12 y

101−178

Female (mg/dL)

0 to 14 d

71−97

15 d to 11 m

53−175

1 to 5 y

80−164

6 to 80 y

116−209

>80 y

114−214

Overview:

Apo A-1 comprises 60% to 70% of the protein content of HDL. Apo A-1 serves as an activator of LCAT which is involved in the transport of cholesterol from peripheral tissues to the liver where it is degraded. Decreased serum HDL cholesterol levels have been reported to correlate with increased risk of coronary artery disease (CAD); however, Apo A-1 has been suggested as a better discrimination of CAD than HDL.1 Apo A-1 levels also correlate with survival rates or risk factors for patients with myocardial infarction and peripheral vascular disease. Measurement of Apo A-1 may also aid in the diagnosis of Tangier disease (absence of alpha-lipoprotein).

1. Maciejko JJ, Holmes DR, Kottke BA, et al. Apolipoprotein A-1 as a marker of angiographically assessed coronary-artery disease. N Engl J Med. 1983; 309(7):385-389. PubMed 6410239

Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May; 58(5):854-868. PubMed 22371482

Collection Details:

Patient Preparation:

Patient must be fasting 12 to 14 hours.

Collection Instructions:

State patient's sex on the test request form.

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube

Separate serum or plasma from cells. Transfer specimen to a plastic transport tube.

Maintain specimen at room temperature.