Celiac Antibodies tTG IgA/IgG With DGP IgA/IgG Positive/Negative Combination Screen

Overview:

For detection of IgA and IgG antibodies to deamidated gliadin-derived peptides (DGP) and human tissue transglutaminase (h-tTG) in human serum. The presence of these antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of IgA-sufficient and IgA-deficient celiac disease.

Aleanzi M, Demonte AM, Esper C, Garcilazo S, Waggener M. Celiac disease: Antibody recognition against native and selectively deamidated gliadin peptides. Clin Chem. 2001 Nov, 47(11):2023-2028. PubMed 11673371

Andersson AS, Holtz A, Backhans B, et al. Inhibition of endomysial staining with human tissue transglutaminase. Ninth International Symposium on Celiac Disease. J Pediatr Gastroenterol Nutr. 2000; 31(S16).

Axiö-Frekricksson UB. Differences in human and guinea pig tissue transglutaminase. Ninth International Symposium on Celiac Disease. J Pediatr Gastroenterol Nutr. 2000; 31(S16).

Bürgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug; 66(8):941-947. PubMed 1819255

Centers for Disease Control and Prevention and National Institutes of Health. Biosafety in Microbiological and Biomedical Laboratories. 5th ed. 2007.

CLSI (NCCLS). Procedures for the Handling and Processing of Blood Specimens; Approved Guideline--Third Edition. CLSI Document H18-A3, 2004, 24(38).

CLSI (NCCLS). Statistical Quality Control for Quantitative Measurement Procedures: Principles and Definitions; Approved Guideline--Third Edition. NCCLS Document C24-A3, 2006, 26(25).

Collin P, Mäki M, Keyriläinen O, Hällström O, Reunala T, Pasternack A. Selective IgA deficiency and coeliac disease. Scand J Gastroenterol. 1992 May; 27(5):367-371. PubMed 1529270

Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul; 3(7):797-801. PubMed 9212111

Hansson T, Dahlbom I, Hall J, et al. Antibody reactivity against human and guinea pig tissue transglutaminase in children with celiac disease. J Pediatr Gastroenterol Nutr. 2000 Apr; 30(4):379-384. PubMed 10776947

Lampasona V, Bazzigaluppi E, Barera G, Bonifacio E. Tissue transglutaminase and combined screening for coeliac disease and type 1 diabetes-associated autoantibodies.Lancet. 1998 Oct 10; 352(9135):1192-1193. PubMed 9777840

Lindh E, Ljunghall S, Larsson K, Lavö B. Screening for antibodies against gliadin in patients with osteoporosis. J Intern Med. 1992 Apr; 231(4):403-406. PubMed 1588266

McMillan SA, Haughton DJ, Biggart JD, Edgar JD, Porter KG, McNeill TA. Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy. BMJ. 1991 Nov 9; 303(6811):1163-1165. PubMed 1747612

Osman AA, Günnel T, Dietl A, et al. B cell epitopes of gliadin. Clin Exp Immunol. 2000 Aug; 121(2):248-254. PubMed 10931138

Prince HE. Evaluation of the INOVA diagnostics enzyme-linked immunosorbent assay kits for measuring serum immunoglobulin G (IgG) and IgA to deamidated gliadin peptides. Clin Vaccine Immunol. 2006 Jan; 13(1):150-151. PubMed 16426013

Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child. 1990; 65(8):909-911. PubMed 2205160

Sárdy M, Odenthal U, Kárpáti S, Paulsson M, Smyth N. Recombinant human tissue transglutaminase ELISA for the diagnosis of gluten-sensitive enteropathy. Clin Chem. 1999 Dec; 45(12):2142-2149. PubMed 10585346

Sblattero D, Berti I, Trevisiol C, et al. Human recombinant tissue transglutaminase ELISA: an innovative diagnostic assay for celiac disease. Am J Gastroenterol. 2000 May; 95(5):1253-1257. PubMed 10811336

Schwertz E, Kahlenberg F, Sack U, et al. Serologic assay based on gliadin-related nonapeptides as a highly sensitive and specific diagnostic aid in celiac disease. Clin Chem. 2004 Dec, 50(12):2370-2375. PubMed 15472035

Signorini M, Bortolotti F, Poltronieri L, Bergamini CM. Human erythrocyte transglutaminase: Purification and preliminary characterisation. Biol Chem Hoppe Seyler. 1988 Apr; 369(4):275-281. PubMed 2900016

Sollid LM, Molberg O, McAdam S, Lundin KE. Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association? Gut. 1997 Dec; 41(6):851-852. PubMed 9462222

Sugai E, Selvaggio G, Vázquez H, et al. Tissue transglutaminase antibodies in celiac disease: Assessment of a commercial kit. Am J Gastroenterol. 2000 Sep; 95(9):2318-2322. PubMed 11007235

Sugai E, Vázquez H, Nachman F, et al. Accuracy of testing for antibodies to synthetic gliadin-related peptides in celiac disease. Clin Gastroenterol Hepatol. 2006 Sep; 4(9):1112-1117. PubMed 16860613

Trier JS. Celiac sprue. N Engl J Med. 1991 Dec 12; 325(24):1709-1719. PubMed 1944472

Troncone R, Ferguson A. Anti-gliadin antibodies. J Pediatr Gastroenterol Nutr. 1991 Feb; 12(2):150-158. PubMed 2051264