Cold Agglutinin Titer, Quantitative

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Turnaround Time: 2 - 3 days
CPT Code:


Test Type: 1 mL Serum
Reference Range:

Negative: <1:32


Detection of the presence of cold agglutinins in patients with suspected cold agglutinin disease.

False-negative results may occur if the sample is refrigerated prior to the separation of the serum from the red blood cells. This test is not a direct measure of the clinical significance of the cold agglutinin and must be used in conjunction with the patient’s clinical presentation and other laboratory values. Normal individuals may have low levels of cold agglutinins that have no clinical significance.

Fung MK, Grossman JB, Hillyer CD, Westoff CM, eds. AABB Technical Manual. 18th ed. Bethesda, Md: American Association of Blood Banks;2014.

Petz LD, Garratty G. Immune Hemolytic Anemias. 2nd ed. New York: Churchill Livingstone/Elsevier Science;2004.

Collection Details:

Collection Instructions:

Red-top tube or gel-barrier tube.

Transport blood immediately to laboratory. Incubate at 37°C and allow to clot at 37°C. Separate serum from cells. If there is not a 37°C incubator, allow to clot at room temperature and separate serum from cells immediately after clotting.

Do not refrigerate prior to separation of serum from red cells. Store separated serum in refrigerator.