Cryptococcus Antigen w/ Reflex*

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Turnaround Time: 2 - 3 days
CPT Code:

87899. If reflex testing is performed, concomitant CPT codes/charges will apply.

Test Type: 2 mL Serum
Stability Time:




72 hours (stability provided by manufacturer or literature reference)


>72 hours (stability provided by manufacturer or literature reference)


Aid in establishing the presence of Cryptococcus neoformans or Cryptococcus gattii infection.

Endpoint titers may not correlate between different methods of cryptococcal antigen testing. Patients with positive cryptococcal antigen results, therefore, should be monitored using the same assay.

Published data for the median sensitivity and specificity for serum specimens are 100% and 99.5%, respectively. False-positive results due to the presence of rheumatoid factor have not been noted with the cryptococcal antigen lateral flow immunochromatographic assay. A negative test does not preclude diagnosis of Cryptococcus infection, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis.

Binnicker MJ, Jespersen DJ, Bestrom JE, Rollins LO. Comparison of four assays for the detection of cryptococcal antigen. Clin Vaccine Immunol. 2012 Dec; 19(12):1988-1990. PubMed 23081814

Klausner JD, Vijayan T, Chiller T. Sensitivity and specificity of a new cryptococcal antigen lateral flow assay in serum and cerebrospinal fluid.MLO. 2013 Mar; 45(3):16,18,20. PubMed 23822028

Collection Details:

Collection Instructions:



Refrigerated (2°-8°C) or frozen (<−20°C)